Publications

Ce livre offre des informations sur les politiques, les pratiques, et les institutions qui sont nécessaires pour améliorer la politique de la réglementation et pour promouvoir une meilleure gouvernance réglementaire.

This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant. A review of regulatory needs for fish tests under various jurisdictions in OECD countries is provided in Chapter 2, followed by a review of statistical issues and general test considerations in Chapters 3 and 4, respectively. The document examines animal welfare concerns and alternatives to fish tests in Chapter 5. Chapter 6 provides a systematic review of existing and draft OECD Guidelines which use fish for toxicity or bioaccumulation studies. Finally Chapter 7 describes a generic framework for assessing the environmental hazards of chemicals using fish tests in the most efficient way. An Annex contains conclusions and recommendations made and agreed at the workshop in September 2010. The recommendations concern, among other aspects, possible improvements to existing Test Guidelines, development of guidance on specific issues, harmonisation of existing Test Guidelines for common issues, development of new Test Guidelines, and proposals for deletion of outdated Test Guidelines.
 

This document describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations, such as obesity/diabetes/metabolic syndrome, reproductive dysfunction, and neuro-developmental abnormalities. Assays and endpoints are described that could be used in new or existing OECD Test Guidelines for evaluating chemicals for endocrine-disrupting activity. Endocrine pathways evaluated are the hypothalamus:pituitary:adrenocortical (HPA) axis, the hypothalamus:pituitary:gonad (HPG) axis, the somatotropic axis, the retinoid signaling pathway, the hypothalamus:pituitary:thyroid (HPT) axis, the vitamin D signaling pathway, and the peroxisome proliferator-activated receptor (PPAR) signaling pathway.

This Emission Scenario Document (ESD) is intended to provide information to be used for risk
assessment for active substances and products used as biocidal (i.e. non agricultural) insecticides, acaricides and products to control other arthropods (in the EU, product type 18 [PT18] c).

This OECD Emission Scenario Document (ESD) provides information on the sources and release pathways of chemicals during their transport and storage in a wide range of industries, to help estimate releases of chemicals into the environment. This ESD covers the transport and storage of chemicals either as pure chemicals or as components of finished products. However, it does not consider the following: mixed waste streams, radioactive substances, biological and infectious materials and foodstuffs.
 

This OECD Emission Scenario Document (ESD) provides information on the sources, use patterns, and potential release pathways of chemicals used in petroleum production at oil wells. The document presents standard approaches for estimating the environmental releases of and occupational exposures to oil production chemicals.

This OECD Emission Scenario Document (ESD) is intended to provide information on the sources, use patterns, and potential release pathways of chemicals to be used in water washing machines at industrial and institutional laundries. The document presents standard approaches for estimating the environmental releases of and occupational exposures to chemicals used in water washing machines in laundries.

This OECD Emission Scenario Document (ESD) provides information on the sources, use patterns, and potential release pathways of chemicals used in the radiation curable products
industry, specifically during application of radiation curable coatings, inks, and adhesives. The document focuses primarily on ultraviolet (UV) and electron beam (EB) curable products and presents standard approaches for estimating the environmental releases of and occupational exposures to components and additives used in radiation curable products.
 

This OECD Emission Scenario Document (ESD) is intended to provide information on the
sources, use patterns and release pathways of chemicals used in the coatings industry (paints,
lacquers and varnishes), to assist in the estimation of releases of chemicals into the environment.
 

This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to those key events. AOPs can be incorporated into chemical categories-based assessments or integrated approaches for testing and assessment.