Publications

This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology for human recombinant in vitro assays to detect substances with estrogen receptor binding affinity (hrER binding assays). It comprises two mechanistically and functionally similar test methods for the identification of estrogen receptor (i.e. ERα) binders and should facilitate the development of new similar or modified test methods. The two reference test methods that provide the basis for this PBTG are: the Freyberger-Wilson (FW) In Vitro Estrogen Receptor (ER) Binding Assay Using a Full Length Human Recombinant ERα, and the Chemical Evaluation and Research Institute (CERI) In Vitro Estrogen Receptor Binding Assay Using a Human Recombinant Ligand Binding Domain Protein. This assay measures the ability of a radiolabeled ligand ([3H]17β-estradiol) to bind with the ER in the presence of increasing concentrations of a test chemical (i.e. competitor).  Test chemicals that possess a high affinity for the ER compete with the radiolabeled ligand at a lower concentration as compared with those chemicals with lower affinity for the receptor. This assay consists of two major components: a saturation binding experiment to characterise receptor-ligand interaction parameters and document ER specificity, followed by a competitive binding experiment that characterises the competition between a test chemical and a radiolabeled ligand for binding to the ER. These test methods are being proposed for screening and prioritisation purposes, but also provide mechanistic information that can be used in a weight of evidence approach.

The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with a tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This Test Guideline is proposed to address a Key Event leading to skin sensitisation, namely keratinocyte activation. This Key Event on the Adverse Outcome Pathway (AOP) leading to skin sensitisation takes place in the keratinocytes and includes inflammatory responses as well as gene expression associated with specific cell signalling pathways such as the antioxidant/electrophile response element (ARE)-dependent pathways. This Test Guideline provides three in vitro test methods addressing the same Key Event on the AOP for skin sensitisation: (i) the ARE-Nrf2 luciferase KeratinoSens™ test method, (ii) the ARE-Nrf2 luciferase LuSens test method and (iii) the Epidermal Sensitisation Assay – EpiSensA. The KeratinoSens and the Lusens are in vitro ARE-Nrf2 luciferase-based test methods and the EpiSensA is based on gene expression quantification using Reverse Transcription- quantitative PCR in reconstructed human epidermis models. The proposed test methods are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. Performance standards have been developed to enable the validation of similar test methods.

Kazakhstan’s trade performance has displayed remarkable resilience to recent economic shocks, including Russia’s full-scale invasion of Ukraine and the ensuing international sanctions. However, connectivity remains one of the greatest challenges facing the country: its trade integration is limited by low density of settlement and economic activity, infrastructure bottlenecks, weaknesses in trade facilitation, and long distances to major markets; its economy still depends on a limited number of export commodities and a narrow range of trading partners. This report summarises the analytical guidance and capacity-building on export diversification in Kazakhstan provided by the OECD in 2022 and 2023. The report complements recent OECD work on trade connectivity in Central Asia, by focusing on practical aspects of export diversification identified in collaboration with the government of Kazakhstan: (i) how to develop export promotion policies for SMEs; (ii) how to design a one-stop shop for exporting SMEs; and (iii) how to improve cross-border co-operation in Kazakhstan’s Caspian Sea ports.

Public procurement measurement frameworks are essential, both to assess progress and achievements periodically and consistently and to identify gaps in progress against objectives and targets. This report assesses the public procurement performance measurement framework in Hungary and provides recommendations for its improvement. It also explores aspects to consider in developing a public procurement measurement framework and communicating the results of the framework.

The global economy relies increasingly on services for economic growth, employment, and innovation. Moreover, services trade plays a crucial role in mitigating some of the biggest challenges of our times, including by strengthening resilience in supply chains, supporting the digital transformation, and enabling a greener economy. Since 2014, the OECD has monitored services trade policies through the OECD Services Trade Restrictiveness Index (STRI), and offers annual updates on data related to services regulations. The STRI identifies opportunities for policy reform, and facilitates the quantification of benefits of open and well-regulated services markets. Building on a decade of monitoring and analysing services policies, this report presents developments on the evolution of the global regulatory and policy environment for services trade. It highlights that services trade barriers remain high and asymmetric across countries and regions, but that ambitious reforms could yield important benefits in terms of trade cost reductions. The report also serves as a unique roadmap for governments to develop ambitious strategies to revitalise services trade and how to leverage the STRI database, indices, and tools in order to implement impactful reforms.

The growing participation of state enterprises in industrial supply chains raises concerns over the implications for global markets of the subsidies that some of these companies receive. New firm-level evidence from the OECD MAGIC database shows that state enterprises are relatively larger recipients of industrial subsidies than their private competitors. They can also benefit from indirect government support, such as favourable treatment under competition rules and government procurement. Despite these advantages, evidence indicates that state enterprises in manufacturing tend to underperform financially. The report provides unprecedented evidence about the role certain state enterprises play as providers of subsidies, such as when providing financing and inputs to other firms at below-market prices. The analysis concludes by describing the implications of these findings for trade rules and the governance of state-owned enterprises.

While means-tested benefits such as minimum income benefits (MIB) and unemployment assistance (UA) are an essential safety net for low-income people and the unemployed, incomplete take-up is the rule rather than the exception. Building on desk research, open-ended surveys and semi-structured interviews, this paper investigates the opportunities and risks of using artificial intelligence (AI) for managing these means-tested benefits. This ranges from providing information to individuals, through determining eligibility based on pre-determined statutory criteria and identifying undue payments, to notifying individuals about their eligibility status. One of the key opportunities of using AI for these purposes is that this may improve the timeliness and take-up of MIB and UA. However, it may also lead to systematically biased eligibility assessments or increase inequalities, amongst others. Finally, the paper explores potential policy directions to help countries seize AI’s opportunities while addressing its risks, when using it for MIB or UA management.

This fourth benchmarking report tracks the evolution of policies and actions on terrorist and violent extremist content (TVEC) implemented by the world’s top 50 most popular online content-sharing services ('popular services') and the top 50 most used services to spread TVEC ('intensive services'). In 2023, 17 popular services issued transparency reports with TVEC-specific information, compared to 15 in 2022, marking the slowest year-to-year growth rate since the benchmarking series began in 2020. Only six intensive services issued transparency reports, down from eight in 2022. The fact that only ten services are both popular and intensive highlights the need to examine beyond the largest platforms. Additionally, as more jurisdictions enact online safety laws, the risk of regulatory fragmentation is increasing. This report underscores the necessity for greater transparency and consistency in the approaches of both services and countries.

A circular economy keeps the value of resources in the economy for longer, extends the useful lifespan of products and reduces waste, thereby reducing environmental and climatic pressures and increasing domestic competitiveness. Italy is among the leading European actors in transitioning to a circular economy. Its adoption of the National Strategy for the Circular Economy in 2022 reinforced the country’s ambition to rapidly shift from linear to circular modes of production and consumption. Among the envisioned measures, the national strategy calls for a stronger use of economic instruments to achieve a more coherent and effective policy mix. This report identifies opportunities for the enhanced use of economic instruments to support the circular economy in Italy. Part I of this report takes stock of the Italian policy landscape, compares it to international practices and recommends seven policy reforms for further consideration. Part II contains an in-depth analysis of three policy instruments that could reduce demand for virgin materials and promote a shift to secondary materials. These instruments include a virgin materials tax on construction minerals, a reduced VAT rate for products with recycled content and corporate tax credits to promote the use of secondary materials.

A small group of small and medium-sized enterprises (SMEs) that grow fast over a short period of time, i.e., scalers, make an outsized contribution to job creation and economic growth. This paper provides a portrait of scalers in the Italian region of Trentino-Alto Adige/Südtirol, and its two autonomous provinces: Trentino and Bolzano-Bozen. The region hosts and attracts a dynamic population of scalers. Around one in nine SMEs in Trentino-Alto Adige/Südtirol is an employment scaler, and more than one in six is a turnover scaler. However, the contribution of the fastest-growing scalers is lower than in the rest of Centre and North Italy, which is in part due to the sectoral specialisation of scalers in the region.