Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity
Tests
Acute toxicity tests are an area of focus for developing alternative assays and approaches
to address animal welfare concerns. In the context of this document, acute toxicity
studies refer to studies involving a single exposure to a test chemical and include
those assessing systemic toxicity as well as those assessing local irritation, corrosion
or sensitization. One approach to minimizing the use of animals for acute toxicity
testing is to consider waiving a study that may be required based on scientific criteria.
Another approach to reducing or eliminating animal testing is to use existing hazard
information that is informative for the acute toxicity endpoint for the test chemical;
this would include the use of hazard information for one or multiple similar test
chemicals to characterize the hazard for another or for mixtures, the use of recognized
calculation approaches and bridging concepts. This Document provides clarification
on these approaches to ensure that regulatory authorities are provided with the appropriate
data required for decision-making and that reduced animal testing can be undertaken
without compromising the integrity of the hazard information.
Published on April 13, 2017
In series:OECD Series on Testing and Assessmentview more titles