Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
This method provides information on health hazard likely to arise from exposure to
test substance via oral administration. The method is based on the repeated oral administration
of the substance of interest during one limited period (one dose level daily during
28 days). This Guideline is intended primarily for use with rodents (rat preferably).
At least 10 animals (5 female and 5 male) should be used for each dose level. Three
tests groups, at least, should be used. The test compound is administered by gavage
or via the diet or drinking water. A limit test may be performed if no effects would
be expected at a dose of 1000 mg/kg bw/d. The report of this study will include results
from clinical and functional observations, body weight and food/water consumption
measurements, hematology and clinical biochemistry; as well as gross necropsy and
histopathology.
Published on October 16, 2008Also available in: French
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