English, PDF, 764kb
11/07/2013 –Recently the OECD released the third generation of the QSAR Toolbox. For this purpose, the guidance document for grouping chemicals to fill data gaps for genetic toxicity and genotoxic carcinogenicity have been updated. This guidance document should support the user of the QSAR Toolbox to build categories that are mechanistically and structurally robust.
English, PDF, 275kb
Global Portal to Information on Chemical Substances, is to be the preferred worldwide source of information about chemicals from authorities and international organisations.
This guidance document intends to provide an insight into which pieces of information that are necessary to identify and document an adverse outcome pathway (AOP) and how to present them. The AOP concept has been developed as a means of providing transparent mechanistic justification and weight-of-evidence to reduce uncertainty in the predictions for complex toxicological endpoints.
This document provides guidance for performing an exposure assessment based on environmental monitoring data.It covers topics such as environmental levels and distribution of contaminants, ways of using monitoring data in exposure assessments for differing purposes, the collection of data, quality of monitoring activities, as well as several examples of data compilation in member countries and their use in exposure assessment.
30/01/2013 –The first update to the third generation of the QSAR Toolbox (version 3.1) has now been released containing improved search functionalities, interface improvement, a new database for observed rat in vivo metabolism; updated auto oxidation and metabolism simulators; updated DNA binding profiler and additional ways of expressing mixtures composition.
30/01/2013 – Recently the OECD release the third generation of the QSAR Toolbox. The existing tutorials and videos have now been updated according to the new version of the QSAR Toolbox to help the user building categories that are mechanistically and structurally robust to maximise success in filling data gaps for the endpoint of interest. Mid next year the OECD is planning to release additional training material.
English, PDF, 34kb
The Toolbox 3.1 installation is a minor update distributed as a standalone installation as well as a patch to Toolbox 3.0. When applying patch, upon first start of the application, an update procedure will be performed on the database. It is a onetime operation that should not be canceled.
US Environmental Protection Agency derived the Human health benchmarks for pesticides by applying the health effects data from pesticide registrations to the typical methods used for developing drinking water health advisories. It was developed to enable states, water systems and the public to better determine whether the detection of a pesticide in drinking water or source waters for drinking water may indicate a potential health risk.
The OECD Environmental Risk Assessment Toolkit describes the work flow for environmental risk assessment and management of chemicals with links to available OECD material relevant for the different steps in risk assessment and management. This new version of the Toolkit is more interactive and has added functionalities. It will be populated with additional tools and case studies in the future.
The aquatic life benchmarks (for freshwater species) are based on toxicity values reviewed by EPA and used in the Agency's most recent risk assessments developed as part of the decision-making process for pesticide registration. Each Aquatic Life Benchmark is based on the most sensitive, scientifically acceptable toxicity endpoint available for a given taxon of all scientifically acceptable toxicity data available to EPA.