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  • 4-November-2021

    English

    Managing the risks from the use of drones for pesticide applications

    The use of UASS for pesticide applications has the potential to improve the sustainability of pesticide use. In order to ensure that potential benefits are realised, suitable data and information must be available to regulators to assess the nature of risks arising from UASS applications. This report looks at a the current state of knowledge and outlines how the risk associated with UASSs applications could be viewed and addressed.

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  • 28-October-2021

    English

    Integrated Approaches to Testing and Assessment (IATA)

    This new case study illustrates an assessment workflow based on various types of non-animal test methods was published in 2021. In addition, an updated document that includes considerations of using methods in IATA was also published following the 6th case study review cycle.

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  • 17-June-2021

    English

    Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists

    This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays). It comprises mechanistically and functionally similar test methods for the identification of estrogen receptor agonists and antagonists and should facilitate the development of new similar or modified test methods. The two reference test methods that provide the basis for this PBTG are: the Stably Transfected TA (STTA) assay using the (h) ERα-HeLa-9903 cell line, derived from a human cervical tumor, and the BG1Luc ER TA assay using the BG1Luc-4E2 cell line, derived from a human ovarian adenocarcinoma. The cell lines used in these assays express ER and have been stably transfected with an ER responsive luciferase reporter gene. The assays are used to identify chemicals that activate (i.e. act as agonists) and also suppress (i.e. act as antagonists) ER- dependent transcription. ER are activated following ligand binding, after which the receptor-ligand complex binds to specific DNA response elements and transactivates the reporter gene, resulting in increased cellular expression of a marker enzyme (e.g. luciferase in luciferase based systems). The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. These test methods are being proposed for screening and prioritisation purposes, but also provide mechanistic information that can be used in a weight of evidence approach.
  • 2-March-2021

    English, PDF, 2,727kb

    Guidance on Key Considerations for the Identification and Selection of Safer Chemical Alternatives

    As the demand for safer chemicals grows, the field of alternatives assessment is becoming increasingly important in guiding the transition towards safer, less toxic alternatives. A major limitation that can hinder efforts is the lack of consistent criteria for defining “safer" alternatives. This guidance outlines key considerations for the identification and selection of safer alternatives.

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  • 2-March-2021

    English

    Substitution of hazardous chemicals

    As the demand for safer chemicals grows, the field of alternatives assessment is becoming increasingly important in guiding the transition towards safer, less toxic alternatives. A major limitation that can hinder efforts is the lack of consistent criteria for defining “safer" alternatives. This guidance outlines key considerations for the identification and selection of safer alternatives.

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  • 12-November-2020

    English

    OECD Work Related to Endocrine Disrupters

    The OECD has published the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.

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  • 12-August-2020

    English

    Pesticide risk reduction

    This page tells about the OECD Pesticide Risk Reduction project.

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  • 25-June-2020

    English

    Emergency responses for the supply of disinfectants against Covid-19

    The COVID-19 pandemic calls for urgent policy responses to support the supply of disinfectant products such as hand sanitisers and wipes. The OECD is collecting and providing available information in countries to manage the emergency supply to increase availability of disinfectant products from different competent authorities and industry organisations.

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  • 18-June-2020

    English

    Who we are and what we do

    Summary on Chemical Safety and Biosafety work at the OECD. While an important focus of the work is on safety aspects of the production, processing and use of industrial chemicals, some work is done on pesticides, chemical accidents, and biotechnology.

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  • 2-March-2020

    English

    Section 3 Software: Environmental Fate and Behaviour (Softwares for TG 305 and TG 318)

    Software to be used for Test Guidelines 305 and 318

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