Latest Documents

12-December-2023

English

Adverse Outcome Pathways

The OECD released three new Adverse Outcome Pathways following scientific review and OECD endorsement.

29-November-2023

English

Webinar Series on Testing and Assessment Methodologies

Two webinars were held by the OECD, which aimed to provide training and orientation on method validation at the OECD, and to help researchers become familiar with method readiness evaluation.

22-November-2023

English

Publications on Minor Uses of Pesticides

This page lists, in chronological order, the Pesticides Publication Series that relate to Minor Uses.

22-November-2023

English

Pesticides publications (Chronological order)

This guidance document collates a variety of existing information regarding the registration of pesticides for minor uses in a centralised document.

26-October-2023

English

OECD Council Acts Related to Chemicals and Biotechnology Products

This new Decision-Recommendation sets out key high-level elements to support the development of a chemical accidents programme covering the fields of prevention, preparedness, and response. It is a consolidation and update of three original OECD legal instruments from 1988 and 2004. It comes with its supporting technical guidance, the Guiding Principles on Chemical Accident Prevention, Preparedness and Response - 3rd edition.

13-October-2023

English

Series on Testing and Assessment: publications by number

The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). The objective is to increase experience with the use of IATA by developing case studies, which constitute examples of predictions that are fit for regulatory use.

18-July-2023

English

Good Laboratory Practice (GLP)

The OECD Principles of Good Laboratory Practice (GLP) ensure the generation of high quality and reliable test data related to the safety of industrial chemical substances and preparations. The principles have been created in the context of harmonising testing procedures for the Mutual Acceptance of Data (MAD).

12-July-2023

English

Ongoing Peer Reviews

Peer review package of the Test Guideline 442C Amino acid Derivative Reactivity Assay (ADRA)

4-July-2023

English

Test No. 405: Acute Eye Irritation/Corrosion

This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. Use of topical anesthetics and systemic analgesics to avoid or minimize pain and distress in ocular safety testing procedures is described.

4-July-2023

English

Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals

This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation. The cell lines used in these assays express AR and have been stably transfected with an AR-responsive luciferase reporter gene, and are used to identify chemicals that activate (i.e. act as agonist) or inhibit (i.e. act as antagonists) AR-dependent transcription. Some chemicals may, in a cell type-dependent manner, display both agonist and antagonist activity and are known as selective AR modulators. The AR is activated following ligand binding, after which the receptor-ligand complex binds to specific DNA responsive elements and transactivates the receptor gene, resulting in an increase cellular expression of the luciferase enzyme. The enzyme then transforms the substrate to a bioluminescent product that can be quantitatively measured with a luminometer. This Test Guideline includes ARTA assays using the AR-EcoScreenTM cell line, the AR-CALUX® cell line, and 22Rv1/MMTV_GR-KO cell line.

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