This Test Guideline (TG) describes the IL-2 Luc Assay test method to evaluate the
potential immunotoxic effects of chemicals on T lymphoblastic cell line. This cell
line allows quantitative measurement of luciferase gene induction by detecting luminescence
from well-established light producing luciferase substrates as indicators of the activity
of IL-2, IFN-γ and GAPDH in cells following exposure to immunotoxic chemicals. The
method is intended to be used as a part of a battery to determine immunotoxic potential
of chemicals.
Published on July 04, 2023Also available in: French
In series:OECD Guidelines for the Testing of Chemicals, Section 4: Health Effectsview more titles