Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder
inflation
This Adverse Outcome Pathway (AOP) describes the linkage between Deiodinase 1 inhibition
and increased mortality via reduced anterior swim bladder inflation. The swim bladder
is a gas-filled organ found in many bony fish species and typically consists of two
gas-filled chambers. The posterior chamber inflates during early development (embryo),
while the anterior chamber inflates during late development (larva). Both chambers
are important for fish to control buoyancy and the anterior chamber has an additional
role in hearing. This AOP is part of a network of 5 AOPs describing how disruption
of the thyroid hormone system can affect developmental processes involved in swim
bladder inflation. The network includes three molecular initiating events representing
the inhibition of enzymes that are important for thyroid hormone synthesis and activation.
It describes how inhibition of thyroperoxidase and/or deiodinase, leads to reduced
swim bladder inflation, resulting in reduced swimming performance, increased mortality
and ultimately, decreased population trajectory in fish. This AOP network is currently
mainly based on experimental evidence from studies on fish species with a two-chambered
swim bladder. This AOP is referred to as AOP 158 in the Collaborative Adverse Outcome
Pathway Wiki (AOP-Wiki).
Available from December 15, 2022
In series:OECD Series on Adverse Outcome Pathwaysview more titles