OECD HomeChemical safety and biosafetyBinding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory - en
Chemical safety and biosafety
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins
involved in protection against oxidative stress during brain development leading to
impairment of learning and memory
This Adverse Outcome Pathway (AOP) describes the linkage between binding to proteins
involved in protection against oxidative stress and impairment in learning and memory.
Production, binding and degradation of Reactive Oxygen Radicals are tightly regulated
in the body, and an imbalance between production and protection may cause oxidative
stress, which is common to many toxicity pathways. Oxidative stress may lead to an
imbalance in glutamate neurotransmission, which is involved in learning and memory.
Oxidative stress may also cause cellular injury and death. During brain development
and in particular during the establishment of neuronal connections and networks, such
perturbations may lead to functional impairment in learning and memory. The weight-of-evidence
supporting the relationship between the key events described in this AOP is based
mainly on developmental effects observed after an exposure to mercury, a heavy metal
known for its strong affinity to many proteins having anti-oxidant properties. This
AOP is referred to as AOP 17 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).
Available from December 15, 2022
In series:OECD Series on Adverse Outcome Pathwaysview more titles