OECD HomeChemical safety and biosafetyAdverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation - en
Chemical safety and biosafety
Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via
impacts on gonad differentiation
This adverse outcome pathway links inhibition of aromatase activity in teleost fish
during gonadogenesis to increased differentiation to testis resulting in a male-biased
sex ratio in the population, and ultimately, reduced population sustainability. Most
gonochoristic fish species develop either as males or females and do not change sex
throughout their life span. However, in species where sexual differentiation is controlled
at least to some degree by environmental factors, there can be a window of development
during gonadal differentiation that is sensitive to a variety of exogenous conditions.
During this window, endocrine active chemicals, aromatase inhibitors in particular,
have the potential to alter gonad development and sex differentiation. This AOP is
referred to as AOP 346 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).
Published on December 12, 2023
In series:OECD Series on Adverse Outcome Pathwaysview more titles