Adverse Outcome Pathway on Androgen receptor agonism leading to male-biased sex ratio
This adverse outcome pathway links androgen receptor agonism in teleost fish during
gonadogenesis to male-biased sexual differentiation and consequently, reduced population
growth rate. Sex determination in teleost fishes is highly plastic; it can be genetically
or environmentally influenced. Species with environmentally-based sex determination
in particular can be very sensitive to exogenous chemicals during the period of differentiation.
Exogenous hormones are of ecological concern because they have the potential to alter
gonad development and sex differentiation. This AOP is referred to as AOP 376 in the
Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).
Published on December 12, 2023
In series:OECD Series on Adverse Outcome Pathwaysview more titles