Fundamental And Guiding Principles For (Q)SAR Analysis Of Chemical Carcinogens with
Mechanistic Considerations
In this document the importance of mechanistic consideration in quantitative structure-activity
relationship ((Q)SAR) analysis, the critical role of mechanistic consideration in
improving various (Q)SAR approaches and possible integrative approaches of combining
chemoinformatics and bioinformatics are discussed, mainly using carcinogenicity as
an illustrative toxicity endpoint. The principles and issues described in this document
are general and may also be used for various types of chemical assessment. The intended
target of readership is for global chemical hazard/risk assessors in regulatory agencies,
industries, non-governmental organization and academia who require reliable and scientifically
supportable (Q)SAR information and predictions in their assessments as well as for
developers/researchers who endeavour to produce scientifically reliable (Q)SAR predictive
models and tools.
Published on April 13, 2017
In series:OECD Series on Testing and Assessmentview more titles