Digital transformations bring about fundamental changes in how institutions – from governments to businesses – operate. National statistical offices (NSOs) face growing expectations from data users and need to adapt their digital capabilities accordingly. For NSOs in low and middle-income countries, who may have had limited exposure to digitalisation to date, keeping pace with rapid technological change is challenging. This report uses examples from six NSOs to explore common barriers for NSOs in their digital transformations and identifies specific drivers. The report makes a case for digital transformations through more comprehensive institutional changes such as governance, procurement and human resources. In addition, the report outlines specific recommendations at the individual, technological, organisational and system level to guide NSOs and their partners towards a successful digital transformation.